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Misfolded or unfolded proteins can accumulate within the ER under stress conditions, such as inflammation, hypoxia, glucose deprivation and oxidative stress, triggering the unfolded protein response (UPR) and inducing ER stress

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If you’re deciding between delivery methods, this breakdown of nasal spray versus injections for peptides covers the bioavailability tradeoffs across routes that also apply to antioxidant compounds